hTFtarget:人类转录因子及其靶标调控的综合数据库。,Genomics, Proteomics & Bioinformatics

hTFtarget:人类转录因子及其靶标调控的综合数据库。,Genomics, Proteomics & Bioinformatics

转录因子(TFs)作为关键调控因子在生物过程中起着至关重要的作用。TF-靶标调控关系的鉴定是揭示TFs功能及其对基因表达调控的关键步骤。染色质免疫沉淀测序(ChIP-seq)的累积数据为发现不同条件下的TF-靶标调控提供了巨大的机会。在这项研究中,我们构建了一个名为hTFtarget的数据库,该数据库集成了庞大的人TF目标资源(659个TF的7190个ChIP-seq样本和699个TF的高可信度结合位点)和表观遗传修饰信息可预测准确的TF-目标法规。hTFtarget为用户提供了以下功能,以探索TF目标规则:(1)在数据集中浏览或搜索查询TF的一般目标;(2)浏览TF-目标法规以查询特定数据集或组织中的TF;(3)搜索给定目标基因或非编码RNA的潜在TF;(4)研究细胞系中TF之间的共缔合;(5)探索给定目标基因或TF的潜在共调控;(6)预测给定DNA序列上的候选TF结合位点;(7)在基因​​组浏览器中可视化不同TF和条件的ChIP-seq峰。hTFtarget提供了全面,可靠且人性化的资源,用于探索人类TF-Target法规,这对于TF和基因表达法规界的广大用户将非常有用。hTFtarget可从http://bioinfo.life.hust.edu.cn/hTFtarget获得。

"点击查看英文标题和摘要"

hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets.

Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF–target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene expression. The accumulated data of chromatin immunoprecipitation sequencing (ChIP-seq) provide great opportunities to discover the TF–target regulations across different conditions. In this study, we constructed a database named hTFtarget, which integrated huge human TF target resources (7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs) and epigenetic modification information to predict accurate TF–target regulations. hTFtarget offers the following functions for users to explore TF–target regulations: (1) browse or search general targets of a query TF across datasets; (2) browse TF–target regulations for a query TF in a specific dataset or tissue; (3) search potential TFs for a given target gene or non-coding RNA; (4) investigate co-association between TFs in cell lines; (5) explore potential co-regulations for given target genes or TFs; (6) predict candidate TF binding sites on given DNA sequences; (7) visualize ChIP-seq peaks for different TFs and conditions in a genome browser. hTFtarget provides a comprehensive, reliable and user-friendly resource for exploring human TF–target regulations, which will be very useful for a wide range of users in the TF and gene expression regulation community. hTFtarget is available at http://bioinfo.life.hust.edu.cn/hTFtarget.

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